Table 2.
Top 10 highly expressed genes in diethylnitrosamine (DEN)-induced tumors in genetic cluster D
| Gene | Fold change vs control (log2) | ||
|---|---|---|---|
| Cirrhosis (CCl4-NT) | CCl4 tumor (CCl4-T) | DEN tumor (DEN-T) | |
| Glypican 3 (Gpc3) | 2.63 | 6.06 | 8.62 |
| Aldo-keto reductase family 1, member C18 (Akr1c18) | 3.26 | 6.44 | 8.57 |
| Flavin containing monooxygenase 3 (Fmo3) | 0.60 | 1.90 | 7.33 |
| ATP-binding cassette, sub-family D, member 2 (Abcd2) | 3.89 | 4.90 | 7.32 |
| Tetraspanin 8 (Tspan8) | 3.92 | 6.29 | 7.23 |
| Alpha fetoprotein (Afp) | 4.19 | 4.47 | 7.11 |
| Trefoil factor 3, intestinal (Tff3) | 0.91 | 6.30 | 6.98 |
| Serine peptidase inhibitor, Kazal type 3 (Spink3) | 6.68 | 6.22 | 6.92 |
| Patatin-like phospholipase domain containing 5 (Pnpla5) | 1.94 | 3.88 | 6.53 |
| Cyclin-dependent kinase inhibitor 2B (Cdkn2b) | 1.84 | 4.73 | 5.96 |
DEN-T, DEN-induced tumor; CCl4-NT, CCl4-induced cirrhotic tissue (non-tumor); CCl4-T, CCl4-induced tumor.