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. 2015 Jun 25;106(8):990–999. doi: 10.1111/cas.12698

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© 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Effects of BRCA1-associated protein 1 (BAP1) mutation on its own nuclear localization. (a) Endogenous WT BAP1 in NCI-H290 showed nuclear localization, whereas mutant BAP1 (p.F679LfsX37) in Y-MESO-9 showed cytoplasmic translocation. (b) Protein expression of exogenously transduced WT or mutant BAP1 (A95D, Y724X, and F679LfsX37) vectors into the malignant mesothelioma cell line with BAP1 deletion (Y-MESO-25). (c) Immunofluorescence analysis of subcellular BAP1 localization with exogenously transduced BAP1 vectors into the Y-MESO-25 cells. (d) Percentages of subcellular localization (c) were calculated. Wild-type BAP1 was mainly localized in the nucleus (N), whereas BAP1 mutants showed translocation in the cytoplasm (C). HD, homozygous deletion.