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. 2015 Jun 25;106(8):990–999. doi: 10.1111/cas.12698

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© 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Irradiation (IR) induces phosphorylation of BRCA1-associated protein 1 (BAP1). (a) Western blot analysis with anti-pS592-BAP1 antibody revealed that endogenous WT BAP1 was phosphorylated after IR at 7.5 Gy. (b) BAP1 phosphorylation levels increased in proportion to IR doses. *Non-specific bands. (c) Immunofluorescence analysis showed dominant nuclear localization of phosphorylated-BAP1 protein at 1 h post-IR (7.5 Gy). (d) Western blot analysis of nuclear/cytoplasmic fractionation tested the localization of exogenously transduced BAP1 and its phosphorylated form in malignant mesothelioma cells with BAP1 deletion. HD, homozygous deletion.