Table 1.
Summary of BAP1 mutations in 25 malignant mesothelioma cell lines
| Cell line | Race | Histological subtypes | Mutation | Amino acid change |
|---|---|---|---|---|
| NCI-H28 | Caucasian | Epithelial | C.438-24_438-2del23† | P.r146afsx48† |
| NCI-H290 | Unknown | ND | WT† | – |
| NCI-H2052 | Caucasian | Epithelial | WT† | – |
| NCI-H2373 | Unknown | ND | WT† | – |
| NCI-H2452 | Caucasian | Epithelial | C.284c>a† | P.a95d† |
| MSTO-211H | Caucasian | Biphasic | WT† | – |
| ACC-MESO-1 | Japanese | Epithelial | WT | – |
| ACC-MESO-4 | Japanese | Epithelial | C.2172delc | P.y724x |
| Y-MESO-8D | Japanese | Biphasic | WT | – |
| Y-MESO-9 | Japanese | Epithelial | C.2035_2036del2 | P.f679lfsx37 |
| Y-MESO-12 | Japanese | Epithelial | WT | – |
| Y-MESO-14 | Japanese | Biphasic | C.349_359del11 | P.k116gfsx5 |
| Y-MESO-21 | Japanese | Epithelial | WT | – |
| Y-MESO-22 | Japanese | Biphasic | WT | – |
| Y-MESO-25 | Japanese | Epithelial | Hd (exon13-17) | Del 417-729 |
| Y-MESO-26B | Japanese | Lymphohistiocytoid | WT | – |
| Y-MESO-27 | Japanese | Epithelial | WT | – |
| Y-MESO-28 | Japanese | Epithelial | WT | – |
| Y-MESO-29 | Japanese | Epithelial | WT | – |
| Y-MESO-30 | Japanese | Epithelial | WT | – |
| Y-MESO-45 | Japanese | ND | WT | – |
| Y-MESO-48 | Japanese | Epithelial | WT | – |
| Y-MESO-61 | Japanese | Epithelial | C.580_581ins40 | P.p195ffsx5 |
| Y-MESO-72 | Japanese | Epithelial | WT | – |
| Y-MESO-76 | Japanese | Epithelial | WT | – |
†
Reported by Bott et al. (2011). –, No change; HD, homozygous deletion; ND, not determined.