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. 2015 Jul 14;106(8):1033–1040. doi: 10.1111/cas.12713

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© 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Downregulation of CRKL by the p53 family. (a) Downregulation of CRKL protein by p53 family in human cancer cell lines. Cells were infected with replication-deficient recombinant adenoviruses encoding human p53 family proteins or the bacterial lacZ for 48 h. CRKL, p53, p73, p63, p21 and β-actin levels were analyzed by immunoblotting. (b) Downregulation of CRKL mRNA by the p53 family in human cancer cell lines. Cells were infected with adenoviruses, and relative gene expression levels were quantified as described above.