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. 2015 Jul 14;106(8):1033–1040. doi: 10.1111/cas.12713

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© 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Endogenous p53 downregulates CRKL mRNA and protein levels. (a) Cells were treated with adriamycin (ADR, 0.5 μg/mL) for 24 h. CRKL and p53 protein levels were determined by immunoblot analysis. β-actin was included as a loading control. Kiku and U2OS have wild type p53, Saos2 cells are deleted for p53, and HOS cells have mutant p53. (b) CRKL mRNA levels were assessed by real-time RT-PCR. (c) The indicated cells were treated with ADR for 16 h. Relative miRNA expression levels were quantified by real-time RT-PCR.