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. 2015 Jul 14;106(8):1050–1056. doi: 10.1111/cas.12717

Figure 1.

Figure 1

Alteration of H3K9 modifications induced by the histone deacetylase (HDAC) inhibitors MS-275 and FK228. (a) U2OS cells were incubated with MS-275 (2.5 μM) or FK228 (2.5 nM) for the indicated times. Whole cell lysates were immunoblotted with the indicated antibodies. (b, c) U2OS (b) or MCF-7 (c) cells were incubated for 24 h with the indicated doses of MS-275 or FK228 and immunoblotted with the indicated antibodies. MS-275 or FK228 did not inhibit the expression levels of DNA repair genes BRCA1, BARD1, RAD51 and 53BP1 at the doses tested.