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Histone deacetylase (HDAC) inhibitors do not show synthetic lethality with a PARP inhibitor. U2OS, HCT116, MCF7 or HeLa cells were exposed to the indicated doses of olaparib with DMSO (alone), MS-275 or FK228 and analyzed for clonogenic survival. The data are shown with nonlinear regression fit curves of one phase decay (GraphPad Prism). Averages ± SEM, normalized to cells without olaparib, were derived from triplicate experiments.
