Table 5.
Results for nine plan groups (3 techniques + 3 MLC) for the evaluated parameters for the meningioma cases (average and standard deviation for five patients): QUANTEC criteria where applicable
| Meningioma | Criteria | Step–and–shoot IMRT | dmlc IMRT | VMAT | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MLCi2− | MLCi2+ | Agility | MLCi2− | MLCi2+ | Agility | MLCi2− | MLCi2+ | Agility | ||||||||||||
| Segmentsa | – | 35.8 ± 10.9 | = | 36.6 ± 11.5 | = | 33.8 ± 11.3 | 158.8 ± 27.5 | = | 159.4 ± 28.9 | = | 158.4 ± 24.9 | 250.4 ± 26.2 | = | 259.8 ± 25.3 | = | 26638 ± 28.1 | 1 | |||
| MU | – | 480.8 ± 140.9 | = | 474.4 ± 128.8 | < | 452.7 ± 124.9 | < | 577.9 ± 166.3 | = | 609.3 ± 194.4 | = | 612.5 ± 175.5 | = | 625.4 ± 125.4 | = | 642.0 ± 143.5 | = | 569.0 ± 95.5 | 2 | |
| Estimated delivery time [s] | – | 290. ± 90.8 | + | 297.5 ± 92.3 | + | 242.1 ± 69.9 | + | 300.9 ± 91.7 | + | 299.5 ± 101.9 | + | 252.4 ± 90.5 | + | 209.4 ± 24.1 | + | 209.0 ± 26.7 | + | 132.3 ± 9.1 | 3 | |
| PTV | EUD | 54 ⇑ | 50.8 ± 2.3 | < | 51.1 ± 1.9 | < | 50.9 ± 2.2 | < | 53.2 ± 0.2 | < | 53.2 ± 0.3 | < | 53.5 ± 0.3 | < | 53.3 ± 0.6 | < | 53.5 ± 0.1 | < | 53.8 ± 0.2 | 4 |
| Dmean | 54⇑ | 52.6 ± 0.6 | < | 52.9 ± 0.5 | < | 52.9 ± 0.5 | < | 53.9 ± 0.2 | < | 53.9 ± 0.2 | < | 54.2 ± 0.2 | < | 54.0 ± 0.4 | < | 54.1 ± 0.1 | < | 54.3 ± 0.2 | 5 | |
| HIICRU | ⇓ | 0.198 ± 0.072 | + | 0.187 ± 0.073 | + | 0.198 ± 0.063 | + | 0.142 ± 0.043 | + | 0.139 ± 0.045 | + | 0.124 ± 0.041 | + | 0.133 ± 0.045 | + | 0.125 ± 0.027 | + | 0.111 ± 0.034 | 6 | |
| CI100 % | ⇑ | 0.267 ± 0.056 | < | 0.284 ± 0.056 | < | 0.323 ± 0.066 | < | 0.499 ± 0.025 | < | 0.492 ± 0.027 | < | 0.590 ± 0.028 | < | 0.523 ± 0.044 | < | 0.539 ± 0.045 | < | 0.638 ± 0.021 | 7 | |
| CI95 % | ⇑ | 0.622 ± 0.117 | < | 0.647 ± 0.102 | < | 0.647 ± 0.107 | < | 0.750 ± 0.059 | = | 0.747 ± 0.057 | = | 0.766 ± 0.062 | = | 0.760 ± 0.044 | = | 0.759 ± 0.057 | = | 0.768 ± 0.055 | 8 | |
| Brainstem | Dmax | 54 | 47.9 ± 10.3 | = | 48.2 ± 10.4 | = | 48.2 ± 10.1 | = | 48.1 ± 10.2 | = | 48.2 ± 10.3 | = | 48.3 ± 10.6 | = | 48.1 ± 10.2 | = | 48.1 = 10.2 | = | 48.3 ± 10.1 | 9 |
| Chiasm | 54 | 53.3 ± 0.7 | = | 53.5 ± 0.4 | = | 53.8 ± 0.3 | = | 53.6 ± 0.4 | = | 53.7 ± 0.3 | = | 53.7 ± 0.3 | = | 53.8 ± 0.3 | = | 53.8 = 0.2 | = | 53.8 ± 0.3 | 10 | |
| Opt. nerve left | 54 | 41.7 ± 15.9 | = | 42.0 ± 16.0 | = | 42.1 ± 16.0 | = | 42.1 ± 16.1 | = | 42.1 ± 16.0 | = | 42.1 ± 16.1 | + | 42.1 ± 15.8 | = | 42.0 = 16.1 | = | 41.9 ± 16.2 | 11 | |
| Opt. nerve right | 54 | 53.7 ± 0.6 | = | 53.9 ± 0.2 | = | 53.8 ± 0.3 | = | 53.8 ± 0.1 | = | 53.9 ± 0.1 | = | 53.8 ± 0.1 | = | 53.8 ± 0.0 | = | 53.9 = 0.1 | = | 53.9 ± 0.1 | 12 | |
| Lens left | ⇓ | 4.0 ± 1.3 | < | 4.1 ± 1.2 | < | 4.1 ± 1.1 | < | 4.9 ± 1.0 | = | 4.7 ± 1.3 | = | 5.0 ± 1.2 | = | 5.9 ± 0.3 | = | 6.1 = 0.0 | = | 6.0 ± 0.1 | 13 | |
| Lens right | ⇓ | 11.1 ± 9.5 | = | 11.3 ± 10.0 | = | 11.1 ± 8.8 | = | 16.0 ± 10.8 | = | 14.9 ± 10.3 | = | 14.4 ± 9.8 | = | 16.7 ± 11.8 | = | 16.9 = 11.4 | = | 16.4 ± 10.2 | 14 | |
| Bulb left | Dmean | ⇓ | 7.9 ± 2.4 | = | 7.7 ± 2.2 | = | 7.5 ± 1.7 | < | 8.4 ± 2.0 | = | 8.3 ± 2.1 | = | 8.5 ± 2.2 | = | 8.9 ± 1.7 | = | 9.1 = 1.5 | = | 9.1 ± 1.5 | 15 |
| Dmax | 54 | 20.0 ± 5.2 | = | 19.8 ± 5.3 | = | 20.2 ± 4.5 | = | 20.5 ± 5.6 | = | 20.1 ± 4.9 | = | 21.5 ± 5.6 | = | 19.3 ± 8.7 | = | 19.7 ± 8.4 | = | 20.1 ± 8.0 | 16 | |
| Bulb right | Dmean | ⇓ | 19.0 ± 7.9 | = | 19.1 ± 8.0 | = | 20.1 ± 8.4 | = | 22.5 ± 10.7 | = | 21.9 ± 10.3 | = | 22.4 ± 10.9 | = | 23.0 ± 11.1 | = | 23.4 ± 11.4 | = | 23.2 ± 10.9 | 17 |
| Dmax | 54 | 40.1 ± 13.4 | = | 39.7 ± 13.3 | = | 40.5 ± 12.7 | = | 41.4 ± 13.9 | = | 41.5 ± 15.0 | = | 41.3 ± 14.3 | = | 41.2 ± 13.9 | = | 41.1 ± 14.6 | = | 41.0 ± 14.5 | 18 | |
| Brain | Dmax | 54 | 53.9 ± 0.8 | < | 54.1 ± 0.8 | < | 54.1 ± 0.9 | < | 54.6 ± 0.6 | < | 54.5 ± 0.7 | < | 54.8 ± 0.7 | = | 54.7 ± 0.8 | < | 54.8 ± 0.6 | < | 54.9 ± 0.6 | 19 |
| V12 Gy | ⇓ | 43.6 ± 16.4 | = | 43.7 ± 16.4 | = | 43.4 ± 15.6 | = | 43.3 ± 15.7 | = | 43.6 ± 16.1 | = | 42.5 ± 16.0 | = | 43.8 ± 14.8 | = | 44.6 ± 14.6 | = | 43.5 ± 13.9 | 20 | |
| A | B | C | D | E | F | G | H | I | ||||||||||||
Arrows indicate if a higher or a lower value gives the better plan. “<”,”+” or “=” indicate whether the result is lower, higher or equal to the VMATAgilty according to comparison α (bold) result on a significance level of 5 %, a for segments: results are compared within each technique to the respective Agility plan according to comparison γ (bold)