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. 2015 Aug 31;10(8):e0134946. doi: 10.1371/journal.pone.0134946

Fig 2. Semi-quantitative analysis of the expression of type I collagen, decorin, TGF-β and the 4/2,4-di-O-sulfated and IdoA-Gal-NAc4S DS domains defined by LKN1 and GD3A12 in the interstitium (A) and glomeruli (B) in renal allograft rejection.

Fig 2

Staining intensities of type I collagen, decorin, transforming growth factor beta (TGF-β) and the DS domains defined by LKN1 and GD3A12 were scored using a scale of 0–4 and revealed a significantly increased tubular interstitial expression of type I collagen, decorin and TGF-β and a decreased expression of the 4/2,4-di-O-sulfated DS domain recognized by LKN1 in interstitial fibrosis and tubular atrophy (IF/TA). Expression of the IdoA-Gal-NAc4S DS domain recognized by GD3A12 was similar in controls and the three types of renal allograft rejection (A). Glomerular expression of the 4/2,4-di-O-sulfated DS domain defined recognized by LKN1 and TGF-β was increased in the acute interstitial, acute vascular and chronic renal allograft rejections compared to controls (B). *P<0.05 vs control.