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. 2015 Jul 21;172(17):4238–4253. doi: 10.1111/bph.13217

Figure 3.

Figure 3

The model of functional allosterism for receptors (Ehlert, 2005; Kenakin, 2005; Price et al., 2005). The receptor R binds a probe A (agonist) and allosteric modulator B according to the Stockton-Ehlert allosteric binding model (Stockton et al., 1983; Ehlert, 1988). The ligand-bound species produce response according to the Black/Leff operational model (Black and Leff, 1983). The parameters quantifying the effect of the modulator are τ for possible direct agonism by the modulator, α for the effect of modulator on the affinity of the receptor for A and β for the effect of the modulator on the efficacy of A.