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Muscarinic agonist responses in guinea pig ileum to oxotremorine and carbachol. Panel furthest to the left shows the control concentration-response curves; oxotremorine is a threefold more potent full agonist than carbachol. Controlled chemical alkylation of receptors with phenoxybenzamine (POB) produces a disparate depression of responses to the low efficacy agonist oxotremorine and resistance to loss of receptors by carbachol. Redrawn from Kenakin (1997).
