. 2015 Jul 21;172(17):4238–4253. doi: 10.1111/bph.13217

Table 2.

Calcium receptor modulator-induced bias

Allosteric ligand	pERK1/2 Δlog(αβ)^a	pERK1/2 bias	PM ruffling Δlog(αβ)^a	PM ruffling bias	IP₁ accumulated Δlog(αβ)^a	IP₁ accumulated bias
PAM
Cinacalcet	−0.19	0.65	−0.07	0.85	0.02	1.05
NPS-R568	−0.16	0.69	−0.24	0.58	0.05	1.12
Calindol	0.18	1.51			−0.06	0.87
S,R-calcimimetic B	0.1	1.26			0.49	3.09
R,R-calcimimetic B	0.2	1.58			0.23	1.70
Nor-calcimimetic B	0.02	1.05			0.15	1.41
AC-265347	0.34	2.19			−0.03	0.93
NAM
NPS-2143	0.29	1.95	0.01	1.02

Data from Davey et al. (2012) and Cook et al. (2015).

Δlog(αβ) = Log(αβ)function − Log(αβ)_{Ca mobilization}.