Figure 3.

The treatment with TC3.6 delays TMEV-IDD progression. TMEV-infected mice were treated with TC3.6 (10 mg·kg⁻¹; n = 6) or appropriate vehicle (0.2% DMSO, Tocrisolve 5% in PBS; n = 6) during pre-symptomatic phase (30 days post-infection) for 12 consecutive days, then were maintained and killed at 70 days after TMEV infection. (A) Clinical score of animals were recorded every 5 days from day 30 until day 50 and every 10 days from day 50 to 70 after TMEV infection. The motor function was analysed (days 30, 45, 60 and 70 post-infection) in an activity cage, including the horizontal activity (B) and the vertical activity (C) for 10 min. ++P < 0.001 versus TMEV + vehicle (30 days); ∧∧P < 0.01 versus TMEV + TC3.6 (30 days), anova for repeated measures #P < 0.05 and ##P < 0.01 versus TMEV + vehicle (on the same day).