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. 2015 Jul 14;172(17):4277–4290. doi: 10.1111/bph.13192

Figure 6.

Figure 6

The treatment with TC3.6 diminishes the expression of pro-inflammatory mediators in spinal cord of TMEV-infected mice. (A) Representative sections of ventral columns of thoracic spinal cord (at day 75 post-infection) of TMEV-infected mice treated with TC3.6 or appropriate vehicle for 14 consecutive days were stained for IL-1β, TNF-α and COX-2. Scale bar 100 μm. The effect of TC3.6 on IL-1β (B), TNF-α (C), IL-6 (D) and IFN-γ (E) mRNA levels in thoracic sections of spinal cord were analysed by semi-quantitative PCR. Each mouse is represented by a circle (O) and the mean of each group is represented by a line (—) (n = 6). *P < 0.05 and **P < 0.01 versus sham; #P < 0.05 and ##P < 0.01 versus TMEV + vehicle.