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. 2015 Jul 14;172(17):4277–4290. doi: 10.1111/bph.13192

Figure 7.

Figure 7

Effects of inhibition of PDE7 by TC3.6 on demyelination and neurodegeneration in the TMEV-IDD model. (A) Representative transverse sections of ventral columns of thoracic spinal cord of TMEV-infected mice treated with TC3.6 or appropriated vehicle (at day 75 post-infection) stained by eriochrome cyanine to visualize myelin; scale bar 50 μm. (B) Representative transverse sections of ventral columns of thoracic spinal cord of TMEV-infected mice treated with TC3.6 or vehicle (at day 75 post-infection) stained with pan-neurofilament; scale bars: 100 and 25 μm; confocal images with constant laser beam were analysed for quantification. (C) Representative longitudinal sections of thoracic spinal cord of TMEV-infected mice treated with TC3.6 or vehicle (at day 75 post-infection) stained with NFH and RIP (CNPase); scale bar 50 and 10 μm. (D) Intensity of pan-neurofilament staining in white matter was quantified. *P < 0.05 versus TMEV + vehicle. (E) Levels of neurofilament (at day 75 post-infection) in spinal cord tissue homogenates were increased by treatment with TC3.6 in TMEV-infected mice. *P < 0.05 versus TMEV + vehicle.