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Effects of the 10 day treatment with CSA (20 mg·kg−1·day−1), Indo (1, 3 or 5 mg·kg−1·day−1) or their combination on serum creatinine and BUN in Sprague-Dawley rats. The effect of endothelin ETA receptor blockade by atrasentan (5 mg·kg−1·day−1) on the CSA–Indo combination is also shown. Values are means ± SEM of six observations. *P < 0.05 versus vehicle; +P < 0.05 versus CSA; #P < 0.05 versus Indo-5; $P < 0.05 versus CSA/Indo-5.
