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. 2015 Jul 30;172(17):4291–4302. doi: 10.1111/bph.13199

Figure 4.

Figure 4

Effects of the 10 day treatment with CSA (20 mg·kg−1·day−1), Indo (5 mg·kg−1·day−1) or their combination on renal necrosis, inflammation, fibrosis and total histology scores. The effect of endothelin ETA receptor blockade by atrasentan (5 mg·kg−1·day−1) on the CSA–Indo combination is also shown. Values are means ± SEM of 6 observations. *P < 0.05 versus vehicle; +P < 0.05 versus CSA; #P < 0.05 versus Indo; $P < 0.05 versus CSA/Indo values.