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. 2015 Jul 30;172(17):4291–4302. doi: 10.1111/bph.13199

Figure 7.

Figure 7

Immunohistochemical ETA receptor expression in renal cortical glomeruli and medullary tubules of Sprague-Dawley rats treated for 10 days with CSA (20 mg·kg−1·day−1), Indo (5 mg·kg−1·day−1) or their combination. The effect of endothelin ETA receptor blockade by atrasentan (5 mg·kg−1·day−1) with the CSA–Indo combination on ETA expression is also shown. Values are means ± SEM of six observations. *P < 0.05 versus vehicle; $P < 0.05 versus CSA/Indo-5. Representative images of immunostained tissues are also shown (400×, A: vehicle; B: CSA; C: Indo; D: CSA + Indo, E: atrasentan + CSA + Indo).