Table 2.

Docking results of matrine and metformin to selected protein targets

Target	Target name	HSP90	HSF1	HSP72	SREBP-1c
	PDB code	3T0Z	2LDU	3ATU	1AM9
Ligand scoring (kcal·mol−1)	Matrine	−6.743	−2.419	−2.878	−1.902
	Metformin	−4.315	−2.480	−4.943	−1.853
	Ganetespib	−7.000	n.d.	n.d.	n.d.

The interactions between matrine or metformin and a series of selected protein targets were simulated by software Schrödinger suite (Schrödinger LLC). X-ray crystal structures of protein targets with relatively high resolution and complete structure were acquired from the Protein Data Bank (http://www.rcsb.org/pdb/). Ganetespib is a reported HSP90 inhibitor. n.d., not determined.