Table 1.
Haemodynamic measurements following chronic drug administration
| LVdP/dtmax (mmHg·s−1) | LVEDP (mmHg) | Heart rate (bpm) | SBP (mmHg) | DBP (mmHg) | H : BW ratio (×1000) | |
|---|---|---|---|---|---|---|
| Vehicle | 4809 ± 484 | −3 ± 2 | 288 ± 20 | 57 ± 3 | 36 ± 2 | 3.31 ± 0.12 |
| Isoprenaline | 4779 ± 169 | 4 ± 3* | 300 ± 5 | 58 ± 2 | 37 ± 2 | 2.91 ± 0.04 |
| Verapamil | 3176 ± 436* | −6 ± 1 | 264 ± 14 | 42 ± 3* | 24 ± 3* | 3.25 ± 0.11 |
| Imatinib | 4938 ± 574 | −6 ± 1 | 318 ± 17 | 55 ± 3 | 28 ± 3 | 3.20 ± 0.11 |
| Sunitinib | 4548 ± 156 | −2 ± 1 | 283 ± 4 | 53 ± 3 | 29 ± 1 | 3.25 ± 0.25 |
DBP, diastolic BP; LVEDP, left ventricular end-diastolic pressure; SBP, systolic BP; H : BW ratio, heart : body weight ratio. Mean ± SEM; n = 6.
*
P < 0.05 compared with vehicle group, one-way anova with Dunnett’s test.