Figure 6.

L6H21 enhanced survival and improved lung injury in LPS-induced septic mice. (A and B) C57BL/6 mice (n = 10 per group) were injected i.v. with 10 mg·kg⁻¹ L6H21 15 min before or after i.v. injection of 20 mg·kg⁻¹ LPS respectively. Survival rates (A) and body weight (B) were recorded for 7 days after LPS injection (** P < 0.01 vs. LPS-treated group). (C) Mice were treated with L6H21 (10 mg·kg⁻¹, i.v.) 15 min before LPS (10 mg·kg⁻¹, i.v.) administration. Mice were killed at 2 h or 8 h after LPS injection. Lung histopathological analysis was performed using H&E staining as described in the Methods section (n = 10 per group).