Figure 5.

Prkce^−/− mice show deeper and more prolonged hypothermia from acute sazetidine-A and nicotine. Drop in mouse skin temperature after injection of (A) 2.0 mg·kg⁻¹ sazetidine-A s.c. in wild-type (n = 15) and Prkce^−/− mice (n = 14), and (B) 2.0 mg·kg⁻¹ nicotine s.c. in wild-type and Prkce^−/− mice (n = 13 per genotype). Skin temperature 24 h after (C) 2.0 mg·kg⁻¹ sazetidine-A (n = 5 wild-type and n = 6 Prkce^−/− mice) and (D) 2.0 mg·kg⁻¹ nicotine injections (n = 4 wild-type and n = 5 Prkce^−/− mice). *P < 0.05, **P < 0.01, ***P < 0.001 compared with wild-type mice at the same time point.