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. 2015 Sep;5(3):481–497. doi: 10.1086/682219

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© 2015 by the Pulmonary Vascular Research Institute. All rights reserved.

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Nonischemic right ventricle versus ischemic right ventricle Ingenuity pathway prediction: networked differentially expressed proteins in the nonischemic and ischemic right ventricles. The 7 differentially expressed proteins used as inputs into Ingenuity are displayed with respect to expression in the nonischemic versus the ischemic right ventricles, with relative upregulation of CRYM, WDR44, DES, ANXA5, and OGN in the nonischemic right ventricles (red) and relative downregulation of SERPINA1 and SERPINC1 in the nonischemic right ventricles (green). In addition to these 7 proteins, predicted changes included activation of serine proteases, PRSS57, MHCII, SMPD2, Ccl6, elastase, CRHR1, TNF, F2, F8, and NFkB and inhibition of anti-inflammatory cytokines, OSMR, FCER2, p38-MAPK, and CX3CR1 (see color code in inset).