Table 3.

Proteomic results for pooled left ventricles (n = 12) versus pooled right ventricles (n = 12)

							Unpaired	Paired
Cluster, protein	UniProt ID	Gene	MW, kDa	Unique peptides	Spectral counts	Peptide covered, %	LV/RV AV ratio	P, t test	LV/RV AV ratio	P, t test
Cluster 1							1.35	0.0005	1.31	0.0035
Mu-crystallin homolog	Q14894	CRYM	34	1	1	3
Cluster 2							1.41	0.012	1.28	0.035
Tropomyosin 1 alpha	B7Z596	TPM1	33	13	14	41
Mu-crystallin homolog	Q14894	CRYM	34	9	12	23
Clusterin	P10909	CLU	52	5	7	13
Cluster 3							1.5	0.01	1.36	0.0057
Tropomyosin 1 alpha	B7Z596	TPM1	33	18	26	41
Mu-crystallin homolog	Q14894	CRYM	34	4	4	14
Cluster 4							1.74	0.003	1.49	0.0034
Tropomyosin 1 alpha	B7Z596	TPM1	33	19	25	42
Cluster 5							2.02	0.008	1.53	0.0066
Thioredoxin-like protein 1	O43396	TXNL1	32	4	5	17
Cluster 6							1.35	0.002	1.33	0.00021
Ubiquinone biosynthesis protein COQ9 (mitochondrial)	O75208	COQ9	36	8	9	22
Cluster 7a							NS	NS	−1.29	0.0054
Troponin I	P19429	TNNI3	24	8	13	32
Serum amyloid P-component	P0DJI8	SAA1	25	7	13	28
ER protein 29	P30040	ERP29	29	6	11	27
Cluster 8b							NS	NS	−1.4	0.0029
Troponin I	P19429	TNNI3	24	7	10	28
Serum amyloid P-component	P0DJI8	SAA1	25	6	10	26
Cluster 9							−2.07	0.0044	−1.58	0.0039
Actinin-2 fragment	P35609	ACTN2	104	9	10	11

^NoteUnique peptides: no. of peptides unique to the parent protein in question identified by tandem mass spectrometry; spectral counts: no. of spectral counts identified by tandem mass spectrometry; peptide covered: percentage of the entire parent peptide identified by the digested peptide fragments identified by tandem mass spectrometry mapped back to the entire parent peptide. AV: average abundance; LV: left ventricle; MW: molecular weight; RV: right ventricle.

^aWeaker evidence for heat-shock protein beta-2 (HSPB2) and NADH dehydrogenase (ubiquinone) iron-sulfur protein 3, mitochondrial (NDUFS3).

^bWeaker evidence for heat-shock protein beta-2 (HSPB2).