Table 6.
Overall DIGE and MS/MS log fold change proteomic expression summary results
| LV/RV ratios | ||||||
|---|---|---|---|---|---|---|
| Protein | Overall | ISCH | N-ISCH | N-RVF | RVF | N-ISCH RV/ISCH RV |
| Metabolic/signaling proteins | ||||||
| Mu-crystalin homolog | 1.4 | 1.7 | 1.3 | 1.4 | 1.3 | 1.5 |
| Thioredoxin-like protein 1 | 2.0 | 2.6 | ||||
| Ubiquinone COQ9 | 1.4 | 1.4 | 1.4 | 1.3 | ||
| ATP synthase subunit d | 1.3 | |||||
| IMMT (mitofilin) | 1.4 | |||||
| Prohibitin | 1.3 | |||||
| Transferrin | ||||||
| NDUFS3 | −1.3* | 1.2* | ||||
| RUVB2 | 1.4 | |||||
| Alpha-1 anti-trypsin | −1.7 | |||||
| Mimecan | 1.5 | |||||
| Heme oxygenase | 1.4 | |||||
| Lactate dehydrogenase | 1.4 | |||||
| Pyruvate dehydrogenase | 1.4 | |||||
| Contractile proteins | ||||||
| Tropomyosin 1 alpha | 1.4 | 2.0 | 1.5 | 2.0 | 1.4* | |
| Troponin I type 3 | −1.3* | 1.8* | 1.2* | |||
| Myosin H 7 | 1.4 | |||||
| Myosin L 3 | 1.3 | |||||
| Cytoskeletal proteins | ||||||
| Actinin-2 fragment | −1.6 | 2.7 | 1.9 | |||
| Desmin | 1.4 | 1.2 | ||||
| WDR44 | 1.4 | 1.2 | ||||
| Survival proteins | ||||||
| Annexin A5 | 1.5 | |||||
| Cathepsin | 1.3 | |||||
| Clusterin | 1.5 | |||||
| Chaperones/stress proteins | ||||||
| ER protein 29 | −1.3* | 1.2 | ||||
| Serum amyloid P (SAA1) | −1.3* | 1.2 | ||||
| HSPB2 | −1.3* | 1.8* | 1.2* | |||
| Miscellaneous/unknown proteins | ||||||
| Fibrinogen | 1.4 | |||||
| Anti-thrombin III | −1.7 | |||||
| RUVB2 (SLMAP) | 1.4 |
Note
P < 0.05 unless otherwise noted. DIGE: differential in-gel electrophoresis; ISCH: ischemic; LV: left ventricle; N-ISCH: nonischemic; N-RVF: hearts without RVF; RV: right ventricle; RVF: right ventricular dysfunction; MS/MS: tandem mass spectrometry.
*
P = 0.05.