Table S2.
Nonischemic LV (n = 6) versus nonischemic RV (n = 6) proteomic results
| Cluster, protein | Gene | MW, kDa | Unique peptides |
Spectral counts |
Peptide covered, % |
LV/RV AV ratio |
P, t test |
|---|---|---|---|---|---|---|---|
| Cluster 1 | 1.36 | 0.028 | |||||
| Mitochondrial inner membrane proteina | IMMT | 84 | 29 | 38 | 31 | ||
| Cluster 2 | 1.29 | 0.029 | |||||
| Mu-crystallin homolog | CRYM | 34 | 1 | 1 | 3 | ||
| Cluster 3 | 1.49 | 0.046 | |||||
| Tropomyosin 1 alpha | TPM1 | 33 | 13 | 14 | 41 | ||
| Mu-crystallin homolog | CRYM | 34 | 9 | 12 | 23 | ||
| Clusterin | CLUS | 52 | 5 | 7 | 13 | ||
| Cluster 4 | 1.43 | 0.026 | |||||
| Tropomyosin 1 alpha | TPM1 | 33 | 19 | 25 | 42 | ||
| Cluster 5 | 1.35 | 0.013 | |||||
| Ubiquinone biosynthesis protein COQ9 (mitochondrial) | COQ9 | 36 | 8 | 9 | 22 | ||
| Cluster 6b | 1.28 | 0.047 | |||||
| ATP synthase subunit d | ATP5H | 18 | 18 | 23 | 43 | ||
| Cluster 7 | 1.3 | 0.056 | |||||
| Cathepsin D | CATD | 45 | 8 | 12 | 14 | ||
| Prohibitin | PHB | 30 | 8 | 10 | 29 |
Note
Unique peptides: no. of peptides unique to the parent protein in question identified by tandem mass spectrometry; spectral counts: no. of spectral counts identified by tandem mass spectrometry; peptide covered: percentage of the entire parent peptide identified by the digested peptide fragments identified by tandem mass spectrometry mapped back to the entire parent peptide. AV: average abundance; LV: left ventricle; MW: molecular weight; RV: right ventricle.
a
Mitofilin, p87/89, cell proliferation-inducing gene 4 protein.
b
Also some background from myosin light chain 3 (MYL3).