Table S3.
Paired LV (n = 8) versus RV dysfunction (n = 8) proteomic results
| Unpaired | Paired | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Cluster, protein | Gene | MW, kDa | Unique peptides |
Spectral counts |
Peptide covered, % |
LV/RV AV ratio |
P, t test |
LV/RV AV ratio |
P, t test |
| Cluster 1 | 1.3 | 0.01 | 1.34 | 0.026 | |||||
| Mu-crystallin homolog | CRYM | 34 | 1 | 1 | 3 | ||||
| Cluster 2 | NS | NS | 1.37 | 0.04 | |||||
| Tropomyosin 1 alpha | TPM1 | 33 | 19 | 25 | 42 | ||||
| Cluster 3 | 1.31 | 0.035 | 1.35 | 0.012 | |||||
| Ubiquinone biosynthesis protein COQ9 (mitochondrial) | COQ9 | 36 | 8 | 9 | 22 | ||||
| Cluster 4a | NS | NS | 1.23 | 0.017 | |||||
| Troponin I | TNNI3 | 24 | 8 | 13 | 32 | ||||
| Serum amyloid P-component | SAMP | 25 | 7 | 13 | 28 | ||||
| ER protein 29 | ERP29 | 29 | 6 | 11 | 27 | ||||
| Cluster 5 | 1.81 | 0.022 | 1.88 | 0.023 | |||||
| Actinin-2 fragment | ACTN2 | 104 | 9 | 10 | 11 |
Note
Unique peptides: no. of peptides unique to the parent protein in question identified by tandem mass spectrometry; spectral counts: no. of spectral counts identified by tandem mass spectrometry; peptide covered: percentage of the entire parent peptide identified by the digested peptide fragments identified by tandem mass spectrometry mapped back to the entire parent peptide. AV: average abundance; LV: left ventricle; MW: molecular weight; NS: not significant; RV: right ventricle.
a
Also weaker evidence for heat-shock protein 27 (HSP27) and NADH dehydrogenase (ubiquinone) iron-sulfur protein 3, mitochondrial (NDUFS3).