Figure 3.

Daily oral treprostinil dose, in milligrams. Median doses were 4.38, 6.0, 9.0, and 11.0 mg/24 h at 3, 6, 12, and 24 months, respectively; mean doses were 4.3 ± 2.3, 6.0 ± 2.1, 8.6 ± 3.2, and 11.7 ± 5.8 mg/24 h, respectively. Circles indicate outliers. *Dashed line: 12 mg, thought to be equivalent to approximately 20 ng/kg/min subcutaneous or intravenous treprostinil.¹⁵