Table 3.
Characteristic | Overall Survival | Disease-free Survival | ||||
---|---|---|---|---|---|---|
HR | 95% CI | P | HR | 95% CI | P | |
Age (years) | 1.030 | 1.008 – 1.051 | 0.006 | 1.030 | 1.009 – 1.052 | 0.005 |
BMI (kg/m2) | 1.009 | 0.985 – 1.033 | 0.482 | 0.991 | 0.966 – 1.017 | 0.507 |
Race | ||||||
Caucasian | 1.0 | - | - | 1.0 | - | - |
African American | 1.454 | 0.633 – 3.340 | 0.378 | 0.980 | 0.358 – 2.684 | 0.969 |
MSI | ||||||
Negative | 1.0 | - | - | 1.0 | - | - |
Positive | 0.783 | 0.460 – 1.334 | 0.368 | 0.874 | 0.498 – 1.532 | 0.638 |
ATR mutation | ||||||
Absent | 1.0 | - | - | 1.0 | - | - |
Present | 1.159 | 0.579 – 2.318 | 0.677 | 0.605 | 0.245 – 1.498 | 0.278 |
Tumor grade | ||||||
1 | 1.0 | - | - | 1.0 | - | - |
2 | 1.281 | 0.733 – 2.240 | 0.385 | 1.302 | 0.753 – 2.250 | 0.345 |
3 | 2.767 | 1.582 – 4.841 | <0.001 | 2.243 | 1.262 – 3.987 | 0.006 |
Tumor grade | ||||||
1 | 1.0 | - | - | 1.0 | - | - |
2 or 3 | 1.750 | 1.059 – 2.892 | 0.029 | 1.597 | 0.970 – 2.627 | 0.066 |
Stage | ||||||
IA | 1.0 | - | - | 1.0 | - | - |
IB/IC | 1.759 | 0.695 – 4.451 | 0.233 | 1.679 | 0.662 – 4.261 | 0.275 |
II | 1.825 | 0.597 – 5.579 | 0.291 | 1.610 | 0.511 – 5.074 | 0.416 |
III/IV | 3.476 | 1.349 – 8.960 | 0.010 | 3.360 | 1.301 – 8.680 | 0.012 |
Stage | ||||||
Early (stage I or II) | 1.0 | - | - | 1.0 | - | - |
Late (stage III or IV) | 2.105 | 1.347 – 3.289 | 0.001 | 2.146 | 1.360 – 3.385 | 0.001 |
LVSI | ||||||
No | 1.0 | - | - | 1.0 | - | - |
Yes | 2.464 | 1.593 – 3.810 | <0.001 | 2.020 | 1.302 – 3.135 | 0.002 |
Myometrial invasion | ||||||
None | 1.0 | - | - | 1.0 | - | - |
Inner half | 1.148 | 0.479 – 2.751 | 0.758 | 1.062 | 0.470 – 2.402 | 0.884 |
Outer half | 3.172 | 1.334 – 7.544 | 0.009 | 2.286 | 1.004 – 5.205 | 0.049 |
Serosa | 8.654 | 3.079 – 24.326 | <0.001 | 5.804 | 2.035 – 16.555 | 0.001 |
Adjuvant treatment | ||||||
No | 1.0 | - | - | 1.0 | - | - |
Yes | 1.368 | 0.889 – 2.106 | 0.154 | 1.476 | 0.947 – 2.299 | 0.085 |