Table 2.

Key input parameters to computer simulation

Parameter description	Point estimate	Range	Source
PrEP characteristics
Relative risk reduction on sexual transmission of HIV associated with PrEP use	44%	25–75%	[1–3]
Relative risk reduction on parenteral transmission of HIV associated with PrEP use	49%	25–75%	[5]
Uptake of PrEP in prioritized population	50%	10–90%	[22, 24, 26, 39–41]
Cost of PrEP per person per year	$9,672	$4,836–19,345	[11, 14, 16]
Population characteristics
Proportion of population who are abstinent	21%	15–25%	[42]
Proportion of men who are MSM (exclusively or non-exclusively)	6%	4–10%	[28]
Probability of monogamous relationship (if sexually active)
Men who have sex with men (MSM)	56%	44%–75%	[28]
Men who have sex with women (MSW)	78%	76%–84%	[28]
Probability of multiple partnerships (if sexually active)
MSM	44%	25%–64%	[28]
MSW	22%	16%–24%	[28]
WSM	9%	7–10%	[28]
Proportion of population that are injection drug users (IDU)	1.4%	1.0–1.9%	[43]
Proportion of IDU that have unsafe injection practices	32%	23%–50%	[44]
Shared injections per year (if unsafe IDU)	70	25–100	Expert opinion
Sex acts (per partnership) per year	89	50–100	[45]
HIV related characteristics
Probability of annual HIV test	31%	10%–50%	[28]
Probability of adherence to ART	63%	50–75%	[46]