Fig 3. Pedigree-tree of a Sphynx cat family segregating a neuromuscular disorder.

Circles represent females, squares represent males. Affected kittens are depicted with fully filled symbols and the proband shown with an arrow. Healthy carriers are depicted with two-toned symbols. Red symbols represent the seven cats from the nuclear family used to map the disease locus; blue symbols represent the four healthy siblings of the proband and the 16 healthy cats directly related to the sire; black symbols represent cats from the extended family. When available, result of the genotyping assay for the c.1190G>A variant is mentioned. The Devon Rex female born in 1990 and known by breeders to have several myopathy healthy carriers in her pedigree is shown (Devon Rex).