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. 2015 Sep 1;10(9):e0135444. doi: 10.1371/journal.pone.0135444

Fig 8. Tumor growing curves of B16 melanoma after CpG/ CpG-construct treatment.

Fig 8

Subcutaneous injection of 1x10^6 B16 melanoma cells at day 0 followed by repetitive treatment (daily) with CpG/ CpG-scrambled RNA/ CpG-siRNA A20 for 7 days. Treatment with 1 nmol CpG/ CpG-constructs started 7 days after B16 cells injection (A), started on day 4 (B) and with 2 nmol CpG/ CpG-constructs starting at day 4 (C). Shown are mean tumor diameters in mm for six mice per group. (D) Statistical dot plot showing tumor diameters in the final phase of all three presented treatments (day 11 after tumor inoculation); n.s. indicates no significant difference, * indicates p<0.05, *** indicates p<0.001 (compared to CpG treated cells, multiple t-test).