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. 2015 Jul 21;28(3):185–194. doi: 10.1007/s12640-015-9547-7

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© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — a The daily clinical motor score served to evaluate the time course of the motor impairment induced by 3NP treatment (day 1–day 8) and its course over the treatment period with AZD3241 or vehicle (day 9–day 30). b Mean clinical motor score per group over the total experimental time indicated lack of effect of AZD3241 treatment (MPOi) on the general motor disability in MSA mice. c Stride length was not changed under MPOi treatment of MSA mice compared to vehicle-treated ones. d, e Rearing and horizontal open field activities were not affected by the MPOi treatment of MSA mice compared to vehicle-treated MSA mice. Data are presented as mean ± SEM. MSA + vehicle group, n = 15, MSA + MPOi group, n = 14