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. 2015 Jul 21;28(3):185–194. doi: 10.1007/s12640-015-9547-7

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© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Nitrated α-synuclein immunohistochemistry in striatum of a, MSA + vehicle and b MSA + MPOi (AZD3241) group. c Statistical analysis indicated significant reduction of the density of GCIs positive for nitrated α-synuclein in the striatum of MSA mice receiving AZD3241 (*p < 0.05; n _vehicle = 10, n _MPOi = 13). Nitrated α-synuclein immunohistochemistry in substantia nigra of d MSA + vehicle and e MSA + MPOi group. f MPOi treatment of MSA mice resulted in significant reduction of GCIs density in substantia nigra (**p < 0.01 compared to MSA + vehicle; n _vehicle = 10, n _MPOi = 14). Nitrated α-synuclein immunohistochemistry in the pontine nuclei of g MSA + vehicle and h MSA + MPOi group. i MPOi treatment of MSA mice resulted in no significant reduction of GCIs density in the pontine nuclei of MSA mice receiving AZD3241 compared to vehicle-treated animals (n _vehicle = 12, n _MPOi = 12). Nitrated α-synuclein immunohistochemistry in the inferior olives of j MSA + vehicle and k MSA + MPOi group. l MPOi treatment of MSA mice resulted in no change in the GCIs density in the inferior olives of MSA mice receiving AZD3241 compared to vehicle-treated animals (n _vehicle = 13, n _MPOi = 12). Nitrated α-synuclein immunohistochemistry in the cerebellar cortex of m MSA + vehicle and n MSA + MPOi group. o MPOi treatment of MSA mice resulted in no change in the GCIs density in the cerebellar cortex of MSA mice receiving AZD3241 compared to vehicle-treated animals (n _vehicle = 11, n _MPOi = 11). Data are presented as mean ± SEM