Table 1.
Properties of LOX enzymes.
Proteins | 15-LOX | 15-LOX-2 | 12-LOX | 12R-LOX | eLOX-3 | 5-LOX | FLAP |
---|---|---|---|---|---|---|---|
Human | |||||||
Gene | ALOX15 | ALOX15B | ALOX12 | ALOX12B | ALOXE3 | ALOX5 | ALOX5AP |
Productsa | 15S-HPETE | 15S-HPETE | 12S-HPETE | 12R-HPETE | Epoxyalcohols | 5S-HPETE | NA |
Expression | Leukocytes | Epithelium, leukocytes | Myeloids, skin, epithelium | Skin, epithelium | Skin, epithelium | Leukocytes | Leukocytes |
Mouse | |||||||
Gene | Alox15 | Alox15b | Alox12 | Alox12b | Aloxe3 | Alox5 | Alox5ap |
Productsa | 12S-, 15S-HPETE | 8R-HPETE, epoxyalcohols | 15S-, 12S-HPETE | 12R-HPETE | Epoxyalcohols | 5S-HPETE | NA |
Expression | Leukocytes | Skin, epithelium, leukocytes | Platelet, skin, epithelium | Skin, epithelium | Skin, epithelium | Leukocytes, epithelium | Leukocytes |
NA, not available. aArachidonic acid as a substrate except eLOX-3 where 12R-HPETE as a substrate.