Table 3.

Phenotypes of LOX-deficient mice.

Genes	Atherosclerosis	Immune response	Neurological disorder	Others
Alox15	↓ in ApoE KO [19–21]	LTC4↑[26]	Peripheral diabetic neuropathy↓[163]	Osteoclast development↑[28]
↓ in LDLR KO [22,23]	Arthritis↑[157]	Diabetic autonomic neuropathy→[163]	Insulin resistance↓[164]
VSMC response↓[24]	Schistosoma mansoni infection→[158]		Angiogenesis↓[165]
Th1↓[159]		Myeloid differentiation↓[27]
IL-12 ↓, TNF-α → [160]		Erythrocyte development→[26]
Acute lung injury↓[161]		Angiogenesis↓[166]
Phagocytosis↑[162]		ER stress↓[167]
Hypertension↓[168]
Inflammatory neovascularization↓[169]
Nonalcoholic fatty liver disease↓[170]
Diabetes associated pp38 and pErk↓[171]
Obesity↓[29]
Ischemic cardioprotection↓[25]
Airway epithelial injury in asthma↓[172]
Alox15b				Epidermal permeability barrier↓ [44]
Alox12		Platelet sensitivity↑[67]		Carcinoma (B6/129)↓[68]
Papilloma (SENCAR)↓[68]
Basal transepidermal water loss↑[69]
Alox12b				Skin barrier↓[87,95]
Ichthyosiform↑[88]
Aloxe3				Skin barrier↓[95]
Alox5	↓ in LDLR KO [114]	PAF-induced lethal shock↓[102,103]	Anxiety-like behavior (C57BL/6)↑[117]	Inflammatory neovascularization↓[169]
OVA-induced asthma↓[108]	Synaptic dysfunction↓[119]	Endotoxin-induced Hypoxic pulmonary vasoconstriction↓[176]
Schistosoma mansoni infection↓[158]	Anxiety-like behavior (B6/129)↓[175]	ApcΔ468-induced intestinal polyposis↓[121–123].
Early female mortality (MRL-lpr/lpr)↓[109]
Toxoplasma gondii elimination↓[107]
Tumor-infiltrating macrophages↑[121]
OVA/alum-induced
Th2↓[159]
Peritonitis↓[105]
LTB4↓[173]
Acute pancreatits↓[104]
Borrelia burgdorferi elimination↓[106]
Histoplasma capsulatum elimination↓[174]
Alox5ap	↓ in COX-2 KO [115]	PAF-induced shock↓[127]	Improved Alzheimer's disease-like phenotype [133]
Zymozan-induced peritonitis↓[127]	Anxiety-like behavior↑[134]
Collagen-induced arthritis↓[129]
Cerebral inflammation↓[128]

ApoE, apolipoprotein E; ARCI, autosomal recessive congenital ichthyosis; KO, knockout; LDLR, low-density lipoprotein receptor.