Fig. 3.

Effects of sulindac and NOSH-sulindac on gastric PGE₂ levels, lipid peroxidation (MDA) and superoxide dismutase (SOD). At the end of the gastrointestinal safety evaluations as described in Section 2.3, tissues from the excised stomachs of each rat was snap frozen in liquid nitrogen and processed as described in Sections 2.4–2.6. SUL and NOSH-SUL caused a significant reduction in gastric mucosal PGE₂ levels (panel A). Results are mean±SEM of 5 rats in each group, ^*P<0.05 vs vehicle group, ^†P<0.05 vs NOSH-SUL group. SUL caused an almost 9-fold increase in MDA levels, for NOSH-SUL-treated rats, MDA levels were about 2-fold higher (panel B). Results are mean±SEM for 5 rats in each group, ^†P<0.01 vs vehicle group, ^§P<0.05 vs SUL group. SUL caused a significant reduction in SOD activity, whereas NOSH-SUL did not have an effect (panel C). Results are mean±SEM of 5 rats in each group, ^†P<0.05 vs vehicle group, ^†P<0.01 vs SUL group.