Fig. 6.

Sulindac and NOSH-sulindac reduce LPS-induced fever, raise the threshold for hyperalgesia, and show anti-platelet activity. Panel A: LPS (50 μg/kg, ip) was administered to the rats one hour before administration of SUL or NOSH-SUL at equimolar doses (0.56 mmol/kg; 200 mg/kg and 467 mg/kg for SUL and NOSH-SUL, respectively). Core body temperature was recorded at 30 min and thereafter hourly for 5 h. Results are mean±SEM for 5 rats in each group, *P<0.01 vs vehicle for both SUL and NOSH-SUL from 1–5 h. Panel B: Mechanical pain threshold was increased in a time-dependent manner by SUL and NOSH-SUL. Results are mean±SEM for 5 rats in each group. ^*P<0.05 vs vehicle for SUL and NOSH-SUL from 2–5 h.Panel C: SUL and NOSH-SUL were equally effective in inhibiting human platelet aggregation. Results are mean±range for two individuals.