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. 2015 Sep 1;6(5):e00981-15. doi: 10.1128/mBio.00981-15

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Copyright © 2015 Diaz Caballero et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

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FIG 6 — Relationship between pbpB alleles and MICs to selected antipseudomonal antibiotics. Pseudomonas aeruginosa isolates were grouped by pbpB genotype based on the presence of major and minor alleles, as well as clade membership in clade A (ancestral) and clade B (sweep) populations. Antibiotic MICs were assayed for aztreonam (A), cefsulodin (B), ceftazidime (C), and piperacillin (D). The presence of the minor alleles was associated with significantly increased resistance to aztreonam and cefsulodin in both clades but to ceftazidime and piperacillin only for the clade A minor allele. Statistical significance was determined by Mann-Whitney U test and is indicated with asterisks. (**, P ≤ 0.01; ***, P ≤ 0.001).