Table 1.
Factors involved in EMT of gynecological cancers.
| Cervical cancer | Ovarian cancer | Endometrial cancer | Vulvar cancer | Vaginal cancer | |
|---|---|---|---|---|---|
| Transcriptional regulators | Snail/Slug/Smuc Zeb1/Zeb2 Twist1/Twist2 E47 |
Snail Zeb1/2 Twist1 KLF4 ETV5 HMGA2 |
Snail/Slug Zeb1 Twist1/Twist2 KLF17 ETV5 HMGA2 |
Snail/Slug Twist2 |
|
|
| |||||
| Growth factors | TGF-β
EGF |
TGF-β
EGF /HB-EGF VEGF HGF FGF |
TGF-β
EGF VEGF IGF1 |
||
|
| |||||
| Oncogenes | HPV16 E6/E7 Sam68 AEG1 FTS |
PIK3CA AKT2 |
BMI-1 | ||
|
| |||||
| Tumor suppressors |
Klotho SFRPs |
P53 SFRPs RASAL2 |
P53 | ||
|
| |||||
| miRNAs | miR-200 family miR-155 miR-361-5p |
miR-200 family miR-181 miR-20a miR-214 |
miR-200 family miR-155 miR-130 |
||
|
| |||||
| Other molecular factors |
β1-integrin receptors MMPs 7/9 IL6 RhoC Gelsolin TBLR1 TACC3 KCC3 EphB2 Nogo-B TNF-α |
β1-integrin receptors MMP 9 IL6 RhoC MUC4/16 ET-1 BMP4 CCR7 TG2 PAK1 MTA1 Sema3E Gb2 FN1 |
ERα
TrkB PR |
ERα/β | |