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The O2-sensing and -signaling pathway in the carotid body
Schematic presentation of CO-regulated H2S generation in type I cells of the carotid body and its impact on sensory nerve activity. HO-2, heme oxygenase 2; sGC, soluble guanylate cyclase; cGMP, cyclic guanosine monophosphate; PKG- II, protein kinase G-II; CSE, cystathionine-ϒ-lyase; ETC, electron transport chain; NT, neurotransmitter.
