Table 3.
Pharmacokinetic parameters of tolbutamide and metoprolol in control group and MGCD0103 group rats (mean ± SD, n = 10).
| Parameters | AUC(0–t) | AUC(0–∞) | t 1/2 | CL | V | C max |
|---|---|---|---|---|---|---|
| ng/mL∗h | ng/mL∗h | h | L/h/kg | L/kg | ng/mL | |
| Tolbutamide | ||||||
| Low | 82724.8 ± 13265.9 | 83176.9 ± 13264.2 | 5.2 ± 1.2 | 0.012 ± 0.002 | 0.090 ± 0.014 | 7939.9 ± 1199.1 |
| Medium | 72448.6 ± 14850.4 | 72761.4 ± 14754.7 | 4.7 ± 1.0 | 0.014 ± 0.003 | 0.093 ± 0.010 | 8038.6 ± 1318.2 |
| High | 64052.9 ± 15988.6∗ | 64353.2 ± 15998.9∗ | 4.4 ± 1.2 | 0.016 ± 0.003∗ | 0.099 ± 0.020 | 6208.9 ± 1115.5 |
| Control | 88701.2 ± 19274.8 | 89852.0 ± 19168.1 | 5.3 ± 0.7 | 0.012 ± 0.004 | 0.088 ± 0.019 | 7343.2 ± 1447.5 |
| Metoprolol | ||||||
| Low | 698.1 ± 348.6 | 703.8 ± 351.6 | 0.8 ± 0.1 | 18.2 ± 10.5 | 21.6 ± 13.5 | 370.7 ± 161.1 |
| Medium | 836.1 ± 499.8 | 843.7 ± 498.4 | 0.7 ± 0.3 | 14.1 ± 4.8 | 15.7 ± 9.1 | 520.9 ± 300.9 |
| High | 1031.8 ± 1261.2 | 1046.4 ± 1258.4 | 1.2 ± 0.4 | 22.9 ± 17.4 | 43.6 ± 39.6 | 1185.3 ± 2379.0 |
| Control | 709.2 ± 255.8 | 724.2 ± 255.8 | 0.8 ± 0.2 | 15.8 ± 6.7 | 18.0 ± 8.6 | 426.1 ± 159.3 |
MGCD0103 group was compared with the control group, ∗ p < 0.05.