A 2-wk period of both HIIT and MICT leads to reductions in immune cell TLR expression. TLR4 was measured on lymphocytes (A), CD14+ monocytes (B), CD15+ neutrophils (C), and TLR2 measured on lymphocytes (D) by flow cytometry before and after training. MFI, median fluorescence intensity. Main effects of time were significant for all (P < 0.05), with a significant group × time interaction for CD15+ neutrophils (P = 0.018). *Significant difference from pretraining within group. There were no significant changes in TLR2 on CD14+ monocytes or CD15+ neutrophils (data not shown).