Table 3.
Results of the significant genotypes associated with cardioembolic stroke in the discovery cohort.
| Gene | Chr | SNP | Position | Genotype | Cases discovery (n = 374) | Controls discovery (n = 156) | OR (CI 95%) | p value discovery | Cases replication (n = 242) | Controls replication (n = 547) | OR (CI 95%) | p value replication |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NOS3 | 7 | rs1800779 | 150992855 | GG versus (AG/GG) | 22.4% | 11.6% | 2.2 (1.11–4.38) | 0.021 | 21.6% | 19.4% | 1.14 (0.64–2.03) | 0.64 |
|
| ||||||||||||
| NOS3 | 7 | rs2257073 | 151186200 | TT versus (CT/CC) | 5.2% | 10.5% | 0.46 (0.22–0.95) | 0.033 | 5.4% | 7.8% | 0.67 (0.24–1.11) | 0.43 |
|
| ||||||||||||
| CRP | 1 | rs1205 | 159712443 | CC versus (CT/TT) | 40.9% | 51.3% | 0.65 (0.44–0.96 | 0.032 | 40.4% | 45.7% | 0.8 (0.58–0.95) | 0.18 |
Chr: chromosome, OR: odds ratio, and CI: confidence interval.