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Deletion of the α-actinin-binding site in ASIC-1 attenuates amiloride-sensitive currents. A and B: current-voltage relationship shows significant attenuation of amiloride-sensitive whole cell conductance in D54MG and U87MG cells expressing mutation of the α-actinin-binding site compared with ASIC-1-overexpressing (WT) cells (n ≥ 7 in each case). **P < 0.01; ***P < 0.001 by Student's t-test.
