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. 2015 Jun 16;47(9):420–431. doi: 10.1152/physiolgenomics.00123.2014

Fig. 3.

Fig. 3.

Enriched gene network constructed using differentially expressed transcripts (FDR <0.05) following exposure to 34.4 ng E2/l. This was the highest scoring enriched network generated by Ingenuity Pathway Analysis (IPA) on default settings. Associated functions of this network include amino acid metabolism, cell death and survival, endocrine system development, and small molecule biochemistry. Nodes represent genes and edges represent gene relationships. The intensity of node shading represents degree of upregulation (red) or downregulation (green), while uncolored nodes represent genes that were not identified as being differentially expressed in our experiment but were included in this network based on evidence stored in IPA databases. Node shapes denote enzymes, phosphatases, kinases, peptidases, G protein-coupled receptor, transmembrane receptor, cytokines, growth factor, ion channel, transporter, translation factor, nuclear receptor, transcription factor, and other. EEF1E1, eukaryotic translation elongation factor 1 epsilon 1; EPRS, glutamyl-prolyl-tRNA synthetase; HSPA8, heat shock 70 kDa protein 8; GRWD1, glutamate-rich WD repeat containing 1; CKB, creatine kinase, brain; TUB84B, tubulin alpha 1-like protein; MCM8, minichromosome maintenance complex component 8; EZH2, enhancer of zeste homolog 2; TRIM35, tripartite motif containing 35; EZH1, enhancer of zeste homolog 1; ATAD3A/ATAS3B, ATPase family, AAA domain containing 3A/3B; GRIK5, glutamate receptor, ionotropic, kainate 5; KDM4A, lysine (K)-specific demethylase 4A; Hsp90, 90 kDa heat shock protein; ESR1, estrogen receptor 1; UBALD1, UBA-like domain containing 1; NIPBL, Nipped-B homolog; MYC, v-myc avian myelocytomatosis viral oncogene homolog; ASS1, argininosuccinate synthase 1; RPS23, ribosomal protein S23; NOC2L, nucleolar complex associated 2 homolog; YBX1, Y box binding protein 1; NCL, nucleolin; POLR1A, polymerase (RNA) I polypeptide A, 194 kDa; SUDS3, suppressor of defective silencing 3 homolog; RBMS2, RNA binding motif, single stranded interacting protein 2; SRP72, signal recognition particle 72 kDa.