Table 2.
List of the 20 most upregulated and downregulated transcripts in fish exposed to 34.4 ng E2/l
| Upregulated |
Downregulated |
||||||
|---|---|---|---|---|---|---|---|
| Symbol | Namea | Fold Changeb | FDR | Symbol | Namea | Fold Changeb | FDR |
| vtg1 | vitellogenin 1 | ↑ >5438 | 4.6E-119 | tat | tyrosine aminotransferase | ↓ 4.6 | 8.9E-9 |
| nots | nothepsin | ↑ >4475 | 5.4E-107 | tgm2l | transglutaminase 2, like | ↓ 186.1 | 3.3E-8 |
| vtg6 | vitellogenin 6 | ↑ >2000 | 1.3E-102 | cbln8 | cerebellin 8 | ↓ 5.7 | 2.6E-7 |
| vtg2 | vitellogenin 2 | ↑ >1100 | 7.3E-92 | hsd3b7 | hydroxy-delta-5-steroid dehydrogenase, 3beta- and steroid delta-isomerase | ↓ 5.4 | 2.8E-7 |
| si:dkey-4c23.3 | vitellogenin 1-1 | ↑ >220 | 9.6E-59 | errfi1 | ERBB receptor feedback inhibitor 1 | ↓ 6.3 | 5.5E-7 |
| vtg3 | vitellogenin 3 | ↑ >825 | 1.4E-56 | igfbp1a | insulin-like growth factor binding protein 1a | ↓ 50.7 | 6.2E-7 |
| zp3a.2 | zona pellucida 3a.2 | ↑ 149 | 1.6E-53 | slc3a2a | solute carrier family 3, member 2a | ↓ 10.4 | 6.8E-7 |
| si:dkey-179j5.2 | family with sequence similarity 20, member C | ↑ >185 | 5.0E-52 | faxdc2 | chromosome 5 open reading frame 4 | ↓ 4.8 | 1.8E-6 |
| zp2.5 | zona pellucida 2.5 | ↑ 77.6 | 1.1E-42 | pnp5a | purine nucleoside phosphorylase 5a | ↓ 27.1 | 2.3E-6 |
| zp3a.1 | zona pellucida 3a.1 | ↑ 161.5 | 1.1E-42 | epha8 | eph receptor A8 | ↓ >21 | 7.5E-6 |
| vtg7 | vitellogenin 7 | ↑ >107 | 8.3E-42 | pfkfb1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | ↓ 30.1 | 8.1E-6 |
| crot | carnitine o-octanoyltransferase | ↑ 54.4 | 4.9E-40 | pptc7a | PTC7 protein phosphatase homolog a | ↓ 6.3 | 9.2E-6 |
| esr1 | estrogen receptor 1 | ↑ 25.7 | 1.6E-37 | si:dkey-238o13.4 | si:dkey-238o13.4 | ↓ 4.5 | 1.8E-5 |
| zp2.2 | zona pellucida 2.2 | ↑ 160.7 | 5.1E-31 | st3gal3b | ST3 beta-galactoside alpha-2,3-sialyltransferase 3b | ↓ 3.8 | 2.4E-5 |
| aqp12 | aquaporin 12 | ↑ 28.6 | 8.4E-31 | ret | ret proto-oncogene receptor tyrosine kinase | ↓ 8.5 | 4.3E-5 |
| lrrc58b | leucine rich repeat containing 58b | ↑ 20.6 | 1.0E-30 | ntng2a | netrin g2a | ↓ 4.9 | 4.9E-5 |
| igfbp5a | insulin-like growth factor binding protein 5a | ↑ >49 | 2.6E-30 | ulk1a | unc-51-like kinase 1a | ↓ 4.7 | 4.9E-5 |
| rdh10a | retinol dehydrogenase 10a | ↑ >108 | 8.8E-28 | grb7 | growth factor receptor-bound protein 7 | ↓ 26.3 | 1.2E-4 |
| slc7a11 | solute carrier family 7, member 11 | ↑ >51 | 8.9E-27 | cldn11a | claudin 11a | ↓ 6.5 | 1.3E-4 |
| lpgat1 | lysophosphatidylglycerol acyltransferase 1 | ↑ 26.0 | 3.0E-25 | slc25a29 | solute carrier family 25, member 29 | ↓ 4.8 | 1.4E-4 |
a
Where there were multiple differentially regulated transcripts assigned the same annotation, only the most significantly regulated transcript is included in this list.
b
For transcripts where no read counts were detected in any of the individuals in one of the groups, a nominal value of 1 count was given to each individual in that group to calculate a fold change value, for visualization purposes, in this table. E2, 17β-estradiol; FDR, false discovery rate.