Table 1.

Genes differentially upregulated in carvedilol-treated mouse hearts

		(Carv/DMSO) Fold Change
Seq. Name	Gene Symbol	Microarray	Real-time PCR
NM_133186	Steap3	16.08	0.88
NM_011315	Saa3	14.51	9.6†
NM_023220	Sppl2a	7.29	0.97
NM_016768	Pbx3	6.69	0.86
NM_025706	Tbc1d15	6.47	0.96
NM_016875	Ybx2	6.45	0.88
NM_011091	Pira4	6.03	2.11*
NM_011088	Pira11	6.01	1.79*
NM_011331	Ccl12	4.45	2.61*
NM_001159567	Meis2	4.2	0.96
NM_001177417	Gm6792	4.12	UD
NM_001164329	Gm6904	3.88	0.69
NM_008624	Mras	3.87	0.9
NM_175273	Fam219b	3.7	0.88
NM_001115085	Tssc4	3.67	0.86
NM_001199940	Serpina3i	3.57	4.96†
NM_011094	Pira7	3.47	1.64*
NM_026405	Rab32	3.45	1.2
NM_027118	Cdk13	3.4	0.96
NM_030729	Nckipsd	3.35	0.92
NM_207245	Zfp870	3.35	0.95
NM_008933	Prm2	3.34	UD
NM_021895	Actn4	3.31	0.77
NM_011116	Pld3	3.24	0.93
NM_001167913	Smok2b	3.24	UD
NM_001178012	Sfxn3	3.14	0.71
NM_026136	Gm3404	2.92	UD
NM_011250	Rbl2	2.91	0.81
NM_001142337	Lmo2	2.9	0.87
NM_207659	Hook3	2.74	0.88
NM_001085419	Gm13102	2.71	2.03*
NM_207671	Zfp318	2.62	0.88
NM_009879	Ift81	2.51	0.86
NM_177191	Sycp2	2.38	0.82
NM_153778	Atoh8	2.36	0.74
NM_026573	Upf3b	2.34	1.17
NM_027980	2310003H01Rik	2.32	0.84
NM_146331	Olfr954	2.27	UD
NM_001033245	Hk3	2.25	1
NM_134065	Epdr1	2.21	0.91
NM_028009	Rpusd1	2.21	0.9
NM_080728	Myh7	2.16	2.09†
NM_021398	Slc43a3	2.1	0.82
NM_026644	Agpat4	2.1	0.73
NM_026909	Thap7	2.09	1.23
NM_080448	Srgap3	2.04	1.07
NM_023292	Pus3	2.04	0.85
NM_008277	Hpd	2.01	2.70*
NM_011144	Ppara	2.01	0.81

The expression of genes identified by microarray analysis (Fig. 1) was verified by real-time RT-PCR analysis. Fold change values represent mean of expression levels from 3 (microarray) or 6 (real-time PCR) independent mice per group. The genes, which are significantly upregulated by carvedilol (Carv) compared with vehicle control (DMSO) in both microarray and real-time PCR analyses, include * or †.

UD, undetectable.

^*P < 0.05 vs. DMSO;

^†P < 0.01 vs. DMSO.