Table 2.

Genes differentially downregulated in carvedilol-treated mouse hearts

		(Carv/DMSO) Fold Change
Seq. Name	Gene Symbol	Microarray	Real-time PCR
NM_001159627	Heph	0.24	0.90
NM_178671	Ubxn10	0.29	UD
NM_001136068	Klrc1	0.31	1.30
NM_001025435	BC053393	0.32	UD
NM_178655	Ank2	0.37	0.87
NM_001044697	Zfp2	0.38	0.92
NM_175408	Tmem139	0.38	1.12
NM_027728	Enkur	0.38	0.19‡
NM_023063	Lima1	0.41	0.65*
NM_178444	Egfl7	0.43	0.64*
NM_001033382	Cacna2d4	0.43	UD
NM_026661	Aar2	0.43	0.94
NM_175280	4930529M08Rik	0.43	0.28‡
NM_001001650	Prss48	0.44	UD
NM_029654	Atg2b	0.44	0.94
NM_009541	Zbtb17	0.44	0.84
NM_025496	Cdrt4	0.44	0.37*
NM_029614	Prss23	0.44	0.31*
NM_001081196	Hnrnpul2	0.45	0.96
NM_021325	Cd200r1	0.45	1.26
NM_024474	Col26a1	0.45	0.16‡
NM_001167879	Gareml	0.45	0.31†
NM_011097	Pitx1	0.45	UD
NM_001114179	Slc25a53	0.46	1.41
NM_177657	D630003M21Rik	0.46	0.51†
NM_177854	Sertm1	0.47	0.63*
NM_001163569	Kif9	0.47	0.50*
NM_028326	Zfp618	0.47	1.05
NM_001024846	Zfp62	0.48	0.91
NM_173375	Fam180a	0.48	0.14‡
NM_019577	Ccl24	0.49	0.52*
NM_027025	Adora3	0.49	0.56*
NM_177919	Tceal5	0.49	0.37†
NM_148944	Chrnb4	0.49	UD

The expression of genes identified by microarray analysis (Fig. 1) was verified by real-time RT-PCR analysis. Fold change values represent mean of expression levels from 3 (microarray) or 6 (real-time PCR) independent mice per group. The genes, which are significantly downregulated by Carv compared with vehicle control (DMSO) in both microarray and real-time PCR analyses, include *, †, or ‡.

^*P < 0.05 vs. DMSO;

^†P < 0.01 vs. DMSO;

^‡P < 0.001 vs. DMSO.